Curcumin Induces Nrf2 Nuclear Translocation and Prevents Glomerular Hypertension, Hyperfiltration, Oxidant Stress, and the Decrease in Antioxidant Enzymes in 5/6 Nephrectomized Rats

Curcumin Induces Nrf2 Nuclear Translocation and Prevents Glomerular Hypertension, Hyperfiltration, Oxidant Stress, and the Decrease in Antioxidant Enzymes in 5/6 Nephrectomized Rats

Renal injury resulting from renal ablation induced by 5/6 nephrectomy (5/6NX) is associated with oxidant stress, glomerular hypertension, hyperfiltration, and impaired Nrf2-Keap1 pathway. The purpose of this work was to know if the bifunctional antioxidant curcumin may induce nuclear translocation o...

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Bibliographic Details
Main Authors: Edilia Tapia, Virgilia Soto, Karla Mariana Ortiz-Vega, Guillermo Zarco-Márquez, Eduardo Molina-Jijón, Magdalena Cristóbal-García, José Santamaría, Wylly Ramsés García-Niño, Francisco Correa, Cecilia Zazueta, José Pedraza-Chaverri
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2012/269039

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