Activation of Platelet NLRP3 Inflammasome in Crohn’s Disease

Activation of Platelet NLRP3 Inflammasome in Crohn’s Disease

Patients with Crohn’s disease (CD) are inclined to have platelet hyperactivity and an increased risk of intestinal micro-thrombosis. However, the mechanisms underlying platelet hyperactivity in CD are not well understood. We investigated the assembly of platelet NLRP3 inflammasome in patients with a...

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Bibliographic Details
Main Authors: Ge Zhang, He Chen, Yifan Guo, Wei Zhang, Qiuyu Jiang, Si Zhang, Liping Han, She Chen, Ruyi Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
NLRP3 inflammasome
Crohn’s disease
platelet hyperactivity
ROS
interleukin-1β
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.705325/full

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