Bronchoalveolar Lavage Fluid Reflects a TH1-CD21low B-Cell Interaction in CVID-Related Interstitial Lung Disease

Bronchoalveolar Lavage Fluid Reflects a TH1-CD21low B-Cell Interaction in CVID-Related Interstitial Lung Disease

BackgroundAbout 20% of patients with common variable immunodeficiency (CVID) suffer from interstitial lung disease (ILD) as part of a systemic immune dysregulation. Current understanding suggests a role of B cells in the pathogenesis based on histology and increased levels of BAFF and IgM associated...

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Bibliographic Details
Main Authors: David Friedmann, Susanne Unger, Baerbel Keller, Mirzokhid Rakhmanov, Sigune Goldacker, Gernot Zissel, Björn C. Frye, Jonas C. Schupp, Antje Prasse, Klaus Warnatz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
common variable immunodeficiency
interstitial lung disease
cytokines
CD21low B cells
TFH and TPH cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.616832/full

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