Features of the course and outcomes of neonatal hepatitis of various etiologies

• Main Authors: N. A. Efremova, L. G. Goryacheva, N. V. Rogozina, L. A. Alekseeva, T. V. Bessonova, M. Y. Kotiv
• Format: Article
• Language: Russian
• Published: Journal Infectology 2014-09-01
• Series: Žurnal Infektologii
• Subjects: neonatal hepatitis; cholestasis; liver fibrosis; elastography; outcomes
• Online Access: https://journal.niidi.ru/jofin/article/view/64

We have performed primary examination of 50 children with neonatal hepatitis. Prevalence of herpes infection as the etiologic agent (40,0%) has been found, as well as parenteral hepatitis, both as an isolated (26,0%) and mixed infections. We conducted a comparative analysis of clinical and laboratory data at initial examination and determined the outcomes of neonatal hepatitis to 12 months of life depending on the etiology. Congenital CMV- etiology hepatitis characterized by more cytolysis, mainly due to aspartate aminotransferase and cholestasis, which is 33,3% of cases combined by acholia and urobiliya. In 50,0% of patients with CMV-hepatitis was detected fibrosis with a mean value of liver elastography 9,9 kPa, which is ІІІ degrees of fibrosis METAVIR scale, whereas in children with primary chronic hepatitis C and concomitant HCV + DNA-virus infection fibrosis was not registered. Despite on the large number of modern non-invasive techniques for determining the degree of hepatic fibrosis, the use of its in children during the first months of life is limited and does not allow to predict disease outcome.