SURFACE MODIFITED MAGNETIC NANOPARTICLES FOR BIOMEDICAL APPLICATION

• Main Authors: G. Yu. Vasyukov, I. V. Mitrofanova, V. V. Ivanova, V. D. Prokopiyeva
• Format: Article
• Language: English
• Published: Siberian State Medical University (Tomsk) 2014-12-01
• Series: Bûlleten' Sibirskoj Mediciny
• Subjects: ultradispersed materials; magnetic nanoparticles; cell biology; nanotoxicology; surface modification
• Online Access: https://bulletin.tomsk.ru/jour/article/view/113

Unique physicochemical properties of nanomaterials arouse a great interest of specialists of various fields. Materials based on nanostructures purchase new mechanical, optical, and electrical properties. Great practical importance is the magnetic properties of materials, structural elements which lie at the nanoscale. Nanomaterials with magnetic properties have been used in drug delivery, magnetic hyperthermia, magnetic separation, and magnetic resonance imaging. Magnetic properties of nanoparticles depend on many factors, such as particle size and shape, chemical properties and lattice type. Magnetic characteristics can be changed by the interaction of particles with the surrounding matrix and neighboring particles.Unfortunately, many studies show that a great disadvantage of the unmodified nanoparticles is their non-specific interaction with the cells, which leads to their accumulation outside the target organs, also to­xicity of nanomaterials and their low colloidal stability. Surface modification of nanoparticles can solve this problem. Development of nanostructures based on magnetic nanoparticles and functionalized by biocompatible agents is one of the main targets of nanobiotechnology.