Transmission analysis of candidate genes for nonsyndromic oral clefts in Brazilian parent-child triads with recurrence

• Main Authors: Aline Lourenço da Silva, Lucilene Arilho Ribeiro, Margaret E Cooper, Mary L Marazita, Danilo Moretti-Ferreira
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Genética 2006-01-01
• Series: Genetics and Molecular Biology
• Subjects: oral clefts; cleft lip; cleft palate
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000300005

Cleft lip and/or palate (CL/P) is a major congenital defect with complex etiology, including multiple genetic and environmental factors. Approximately two thirds of the cases are not accompanied by other anomalies and are called nonsyndromic (NS). In the present study, we performed transmission distortion analysis of the MSX1-CA, TGFB3-CA and MTHFR-C677T polymorphisms in 60 parent-child triads, in which the NS-CL/P affected child had at least one affected parent. No association with genes MSX1 or TGFB3 was found, but the results were suggestive of an association of the MTHFR-C677T polymorphism with NS-CL/P.