HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein

HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein

<p>Abstract</p> <p>Background</p> <p>The discovery of diketoacid-containing derivatives as inhibitors of HIV-1 Integrase (IN) (IN inhibitors, IINs) has played a major role in validating this enzyme as an important target for antiretroviral therapy. Since the <it>i...

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Bibliographic Details
Main Authors: Cara Andrea, Andreotti Mauro, Galluzzo Clementina, Verdoliva Antonio, Costi Roberta, Molinari Agnese, Dupuis Maria, Cianfriglia Maurizio, Di Santo Roberto, Palmisano Lucia
Format: Article
Language:English
Published: BMC 2007-03-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/4/1/17

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