H2S- and NO-signaling pathways in Alzheimer’s amyloid vasculopathy: synergism or antagonism?

H2S- and NO-signaling pathways in Alzheimer’s amyloid vasculopathy: synergism or antagonism?

Alzheimer’s type of neurodegeneration dramatically affects H2S and NO synthesis and interactions in the brain, which results in deregulated vasomotor function, brain tissue hypoperfusion and hypoxia, development of perivascular inflammation, promotion of Aβ deposition, and impairment of neurogenesis...

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Bibliographic Details
Main Authors: Alla B. Salmina, Yulia K. Komleva, István András Szijártó, Yana V. Gorina, Olga eLopatina, Galina E. Gertsog, Milos R. Filipovic, Maik eGollasch
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Physiology
Subjects:
Obesity
NO
KCNQ channels
H2S
Vascular Dysfunction
Alzheimer disease (AD)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00361/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00361/full

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