The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.

The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.

RecQ DNA helicases are critical for preserving genome integrity. Of the five RecQ family members identified in humans, only the Werner syndrome protein (WRN) possesses exonuclease activity. Loss of WRN causes the progeroid disorder Werner syndrome which is marked by cancer predisposition. Cellular e...

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Bibliographic Details
Main Authors: Patricia L Opresko, Gregory Sowd, Hong Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2653227?pdf=render

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