Methylome profiling of healthy and central precocious puberty girls

Methylome profiling of healthy and central precocious puberty girls

Abstract Background Recent studies demonstrated that changes in DNA methylation (DNAm) and inactivation of two imprinted genes (MKRN3 and DLK1) alter the onset of female puberty. We aimed to investigate the association of DNAm profiling with the timing of human puberty analyzing the genome-wide DNAm...

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Main Authors: Danielle S. Bessa, Mariana Maschietto, Carlos Francisco Aylwin, Ana P. M. Canton, Vinicius N. Brito, Delanie B. Macedo, Marina Cunha-Silva, Heloísa M. C. Palhares, Elisabete A. M. R. de Resende, Maria de Fátima Borges, Berenice B. Mendonca, Irene Netchine, Ana C. V. Krepischi, Alejandro Lomniczi, Sergio R. Ojeda, Ana Claudia Latronico
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Clinical Epigenetics
Subjects:
Human puberty
Central precocious puberty
DNA methylation
Epigenetics
Genomic imprinting
Zinc finger genes
Online Access:http://link.springer.com/article/10.1186/s13148-018-0581-1

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