Chronic L-DOPA administration increases the firing rate but does not reverse enhanced slow frequency oscillatory activity and synchronization in substantia nigra pars reticulata neurons from 6-hydroxydopamine-lesioned rats

Chronic L-DOPA administration increases the firing rate but does not reverse enhanced slow frequency oscillatory activity and synchronization in substantia nigra pars reticulata neurons from 6-hydroxydopamine-lesioned rats

The pathophysiology of Parkinson's disease (PD) and of L-DOPA-induced dyskinesia (LID) is associated with dysfunctional neuronal activity in several nuclei of the basal ganglia. Moreover, high levels of oscillatory activity and synchronization have also been described in both intra- and inter-b...

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Bibliographic Details
Main Authors: A. Aristieta, J.A. Ruiz-Ortega, C. Miguelez, T. Morera-Herreras, L. Ugedo
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Dyskinesia
In vivo extra-unit recording
Oscillatory activity
Synchronization
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300249

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http://www.sciencedirect.com/science/article/pii/S0969996116300249

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