Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells.

OBJECTIVE:Rho-associated kinase (ROCK) signaling pathway has been shown to mediate various cellular functions including cell proliferation, migration, adhesion, apoptosis, and contraction, all of which may be involved in pathogenesis of atherosclerosis. Endogenous nitric oxide (NO) is well known to...

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Bibliographic Details
Main Authors: Tatsuya Maruhashi, Kensuke Noma, Yumiko Iwamoto, Akimichi Iwamoto, Nozomu Oda, Masato Kajikawa, Takeshi Matsumoto, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Ayumu Nakashima, Chikara Goto, James K Liao, Yukihito Higashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4184841?pdf=render