Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle

Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle

Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expr...

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Main Authors: Tsuey-Pin Lin, Ya-Fang Chiu, Li-Kwan Chang, Ching-Yi Yiu, Shih-Ying Chen
Format: Article
Language:English
Published: MDPI AG 2010-10-01
Series:Molecules
Subjects:
resveratrol
antiviral activity
EBV
Online Access:http://www.mdpi.com/1420-3049/15/10/7115/
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spelling doaj-2d350b7755ad492aa61fda7868bc09762020-11-24T22:02:00ZengMDPI AGMolecules1420-30492010-10-0115107115712410.3390/molecules15107115Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic CycleTsuey-Pin LinYa-Fang ChiuLi-Kwan ChangChing-Yi YiuShih-Ying ChenReactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus. http://www.mdpi.com/1420-3049/15/10/7115/resveratrolantiviral activityEBV
collection DOAJ
language English
format Article
sources DOAJ
author Tsuey-Pin Lin
Ya-Fang Chiu
Li-Kwan Chang
Ching-Yi Yiu
Shih-Ying Chen
spellingShingle Tsuey-Pin Lin
Ya-Fang Chiu
Li-Kwan Chang
Ching-Yi Yiu
Shih-Ying Chen
Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
Molecules
resveratrol
antiviral activity
EBV
author_facet Tsuey-Pin Lin
Ya-Fang Chiu
Li-Kwan Chang
Ching-Yi Yiu
Shih-Ying Chen
author_sort Tsuey-Pin Lin
title Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title_short Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title_full Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title_fullStr Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title_full_unstemmed Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title_sort inhibitory effects of resveratrol on the epstein-barr virus lytic cycle
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2010-10-01
description Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.
topic resveratrol
antiviral activity
EBV
url http://www.mdpi.com/1420-3049/15/10/7115/
work_keys_str_mv AT tsueypinlin inhibitoryeffectsofresveratrolontheepsteinbarrviruslyticcycle
AT yafangchiu inhibitoryeffectsofresveratrolontheepsteinbarrviruslyticcycle
AT likwanchang inhibitoryeffectsofresveratrolontheepsteinbarrviruslyticcycle
AT chingyiyiu inhibitoryeffectsofresveratrolontheepsteinbarrviruslyticcycle
AT shihyingchen inhibitoryeffectsofresveratrolontheepsteinbarrviruslyticcycle
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