Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle

Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle

Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expr...

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Bibliographic Details
Main Authors: Tsuey-Pin Lin, Ya-Fang Chiu, Li-Kwan Chang, Ching-Yi Yiu, Shih-Ying Chen
Format: Article
Language:English
Published: MDPI AG 2010-10-01
Series:Molecules
Subjects:
resveratrol
antiviral activity
EBV
Online Access:http://www.mdpi.com/1420-3049/15/10/7115/
Description
Summary:Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.
ISSN:1420-3049

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