Deferoxamine Promotes MDA-MB-231 Cell Migration and Invasion through Increased ROS-Dependent HIF-1α Accumulation

Deferoxamine Promotes MDA-MB-231 Cell Migration and Invasion through Increased ROS-Dependent HIF-1α Accumulation

Background/Aim: Deferoxamine (DFO), an iron chelator, has been reported to induce hypoxia-inducible factor-1α (HIF-1α) expression. HIF-1α plays a critical role in promoting tumor metastasis. However, the molecular mechanisms underlying induction of HIF-1α in breast cancer cells remain unknown. Our a...

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Bibliographic Details
Main Authors: Yiping Liu, Yongfeng Cui, Miao Shi, Qiang Zhang, Qiang Wang, Xiaodong Chen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Reactive oxygen species
Deferoxamine
Hypoxia-inducible factor-1α
Extracellular signal-regulated kinase 1/2
Breast cancer
Online Access:http://www.karger.com/Article/FullText/358674

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http://www.karger.com/Article/FullText/358674

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