Linkage analysis between dominant and co-dominant makers in full-sib families of out-breeding species

• Main Authors: Alexandre Alonso Alves, Leonardo Lopes Bhering, Cosme Damião Cruz, Acelino Couto Alfenas
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Genética 2010-01-01
• Series: Genetics and Molecular Biology
• Subjects: statistical genomics; exogamic populations; recombination frequency and maximum likelihood
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300021

As high-throughput genomic tools, such as the DNA microarray platform, have lead to the development of novel genotyping procedures, such as Diversity Arrays Technology (DArT) and Single Nucleotide Polymorphisms (SNPs), it is likely that, in the future, high density linkage maps will be constructed from both dominant and co-dominant markers. Recently, a strictly genetic approach was described for estimating recombination frequency (r) between co-dominant markers in full-sib families. The complete set of maximum likelihood estimators for r in full-sib families was almost obtained, but unfortunately, one particular configuration involving dominant markers, segregating in a 3:1 ratio and co-dominant markers, was not considered. Here we add nine further estimators to the previously published set, thereby making it possible to cover all combinations of molecular markers with two to four alleles (without epistasis) in a full-sib family. This includes segregation in one or both parents, dominance and all linkage phase configurations.