Intra- and inter-subunit disulfide bond formation is nonessential in adeno-associated viral capsids.

Intra- and inter-subunit disulfide bond formation is nonessential in adeno-associated viral capsids.

The capsid proteins of adeno-associated viruses (AAV) have five conserved cysteine residues. Structural analysis of AAV serotype 2 reveals that Cys289 and Cys361 are located adjacent to each other within each monomer, while Cys230 and Cys394 are located on opposite edges of each subunit and juxtapos...

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Bibliographic Details
Main Authors: Nagesh Pulicherla, Pradeep Kota, Nikolay V Dokholyan, Aravind Asokan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3289628?pdf=render

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