Short-term results in canines of novel stent-graft design for chimney technique in TEVAR

• Main Authors: Ming Li, Chang Shu, Benhao Xiao, Dingxiao Liu, Weichang Zhang
• Format: Article
• Language: English
• Published: KeAi Communications Co., Ltd. 2020-09-01
• Series: Journal of Interventional Medicine
• Subjects: Thoracic endovascular aortic repair; Chimney technique; Canine model; In vivo experiment; Stent-graft
• Online Access: http://www.sciencedirect.com/science/article/pii/S2096360220300417

Introduction: Parallel stent-stent grafting is a major endovascular technique used to preserve the supra-aortic branches during thoracic endovascular aortic repair (TEVAR) of aortic pathologies involving the aortic arch. The short- and mid-term results of this technique are satisfactory; however, endoleak remains a major concern. Thus, here we designed a new chimney stent-graft to decrease the endoleak rate. Aim: To testify the feasibility and safety of the new chimney stent-graft system in a canine model. Material and methods: Six Labrador retrievers were used. Pre-operative data were collected and all operations were performed under general anesthesia. The main and chimney stent-grafts were implanted through the abdominal aorta and left subclavian artery approaches, respectively. Completion digital subtraction angiography (DSA) was performed to confirm the immediate outcomes. All dogs were fed separately for 6 months and sacrificed after aortic angiography. The thoracic aorta and the main and chimney stent-grafts were harvested for histopathologic examination. Results: No complications were found in follow-up DSA. All branch arteries were patent. Inflammatory responses were observed around the stent-grafts in 3 experimental animals, and slight hyperplasia was observed in the surrounding tissues compared with the normal vessels. There was no mural thrombus in the stent, endothelial cells were noted on the inner surface of the stent, and thrombus was formed in the outer skirt and gutter area. The histopathologic examinations revealed similar results to those of gross necropsy observations. Conclusions: This study demonstrated the feasibility and safety of the Longuette stent-graft and the first to report a revised stent-graft specific for chimney technique.