The role of tumour suppressor PDCD4 in beta cell death in hypoxia.

The role of tumour suppressor PDCD4 in beta cell death in hypoxia.

Hypoxia is known to induce pancreatic beta cell dysfunction and apoptosis. Changes in Programmed Cell Death Gene 4 (PDCD4) expression have previously been linked with beta cell neogenesis and function. Our aim was to investigate the effects of hypoxia on cell viability, PDCD4 expression and subcellu...

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Bibliographic Details
Main Authors: Sandeep Kumar, Claire E Marriott, Nouf F Alhasawi, Adrian J Bone, Wendy M Macfarlane
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5531437?pdf=render

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