A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy.

A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy.

Depending on the epidemiological setting, a variable proportion of leprosy patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions (T1R). The LRRK2 gene encodes a multi-functional protein that has been shown to modulate pro-inflammatory responses. Variants near the LR...

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Bibliographic Details
Main Authors: Vinicius M Fava, Jérémy Manry, Aurélie Cobat, Marianna Orlova, Nguyen Van Thuc, Nguyen Ngoc Ba, Vu Hong Thai, Laurent Abel, Alexandre Alcaïs, Erwin Schurr, Canadian Lrrk2 in Inflammation Team (CLINT)
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4742274?pdf=render

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