A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases

A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases

How G-quadruplexes (G4s) are resolved by helicases is still a matter of investigation. Here the authors provide mechanistic insight into G4s unwinding by presenting a crystal structure of resolved G4 DNA and the G4 binding domain of RecQ helicase from the bacterium Cronobacter sakazakii.

Bibliographic Details
Main Authors: Andrew F. Voter, Yupeng Qiu, Ramreddy Tippana, Sua Myong, James L. Keck
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06751-8
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spelling doaj-2d0ad37a45eb4231a16e4299162f5d0e2021-05-11T10:17:51ZengNature Publishing GroupNature Communications2041-17232018-10-01911810.1038/s41467-018-06751-8A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicasesAndrew F. Voter0Yupeng Qiu1Ramreddy Tippana2Sua Myong3James L. Keck4Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public HealthDepartment of Biophysics, Johns Hopkins UniversityDepartment of Biophysics, Johns Hopkins UniversityDepartment of Biophysics, Johns Hopkins UniversityDepartment of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public HealthHow G-quadruplexes (G4s) are resolved by helicases is still a matter of investigation. Here the authors provide mechanistic insight into G4s unwinding by presenting a crystal structure of resolved G4 DNA and the G4 binding domain of RecQ helicase from the bacterium Cronobacter sakazakii.https://doi.org/10.1038/s41467-018-06751-8
collection DOAJ
language English
format Article
sources DOAJ
author Andrew F. Voter
Yupeng Qiu
Ramreddy Tippana
Sua Myong
James L. Keck
spellingShingle Andrew F. Voter
Yupeng Qiu
Ramreddy Tippana
Sua Myong
James L. Keck
A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
Nature Communications
author_facet Andrew F. Voter
Yupeng Qiu
Ramreddy Tippana
Sua Myong
James L. Keck
author_sort Andrew F. Voter
title A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
title_short A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
title_full A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
title_fullStr A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
title_full_unstemmed A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
title_sort guanine-flipping and sequestration mechanism for g-quadruplex unwinding by recq helicases
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-10-01
description How G-quadruplexes (G4s) are resolved by helicases is still a matter of investigation. Here the authors provide mechanistic insight into G4s unwinding by presenting a crystal structure of resolved G4 DNA and the G4 binding domain of RecQ helicase from the bacterium Cronobacter sakazakii.
url https://doi.org/10.1038/s41467-018-06751-8
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