Lysosomal acid lipase: At the crossroads of normal and atherogenic cholesterol metabolism

Lysosomal acid lipase: At the crossroads of normal and atherogenic cholesterol metabolism

Unregulated cellular uptake of apolipoprotein B-containing lipoproteins in the arterial intima leads to the formation of foam cells in atherosclerosis. Lysosomal acid lipase (LAL) plays a crucial role in both lipoprotein lipid catabolism and excess lipid accumulation as it is the primary enzyme that...

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Bibliographic Details
Main Authors: Joshua A Dubland, Gordon A Francis
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Foam Cells
Macrophages
oxidized LDL
atherosclerosis.
smooth muscle cells
lysosomal storage disorders
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00003/full

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