The hypoxia conditioned mesenchymal stem cells promote hepatocellular carcinoma progression through YAP mediated lipogenesis reprogramming

The hypoxia conditioned mesenchymal stem cells promote hepatocellular carcinoma progression through YAP mediated lipogenesis reprogramming

Abstract Background Tumor microenvironment (TME) plays a very important role in cancer progression. The mesenchymal stem cells (MSC), a major compartment of TME, have been shown to promote hepatocellular carcinoma (HCC) progression and metastasis. As hypoxia is a common feature of TME, it is essenti...

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Bibliographic Details
Main Authors: Yang Liu, Haozhen Ren, Yuan Zhou, Longcheng Shang, Yuheng Zhang, Faji Yang, Xiaolei Shi
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hypoxia
Mesenchymal stem cells
YAP
Lipogenesis
Online Access:http://link.springer.com/article/10.1186/s13046-019-1219-7

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http://link.springer.com/article/10.1186/s13046-019-1219-7

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