The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis

The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis

R2TP was originally identified in yeast Saccharomyces cerevisiae as Hsp90 interacting complex, and is composed of four different proteins: Rvb1, Rvb2, Tah1, and Pih1. This complex is well-conserved in eukaryotes, and is involved in many cellular processes such as snoRNP biogenesis, RNA polymerase as...

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Main Authors: Kakihara Yoshito, Saeki Makio
Format: Article
Language:English
Published: De Gruyter 2014-12-01
Series:Biomolecular Concepts
Subjects:
box c/d snornp
box h/aca snornp
r2tp
snornp biogenesis
tumorigenesis
Online Access:https://doi.org/10.1515/bmc-2014-0028
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spelling doaj-2cea3e20cfa644069a8ac078aa3ed2852021-09-05T20:42:34ZengDe GruyterBiomolecular Concepts1868-50211868-503X2014-12-015651352010.1515/bmc-2014-0028The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesisKakihara Yoshito0Saeki Makio1Division of Dental Pharmacology, Department of Dentistry, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, JapanDivision of Dental Pharmacology, Department of Dentistry, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, JapanR2TP was originally identified in yeast Saccharomyces cerevisiae as Hsp90 interacting complex, and is composed of four different proteins: Rvb1, Rvb2, Tah1, and Pih1. This complex is well-conserved in eukaryotes, and is involved in many cellular processes such as snoRNP biogenesis, RNA polymerase assembly, PIKK signaling, and apoptosis. An increasing number of research related to R2TP suggests a linkage of its function with tumorigenesis. In this review, we provide an overview of several recent studies on R2TP that are related to cell proliferation and carcinogenesis, and propose a possible role of R2TP in tumorigenesis through regulating snoRNA/snoRNP biogenesis.https://doi.org/10.1515/bmc-2014-0028box c/d snornpbox h/aca snornpr2tpsnornp biogenesistumorigenesis
collection DOAJ
language English
format Article
sources DOAJ
author Kakihara Yoshito
Saeki Makio
spellingShingle Kakihara Yoshito
Saeki Makio
The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis
Biomolecular Concepts
box c/d snornp
box h/aca snornp
r2tp
snornp biogenesis
tumorigenesis
author_facet Kakihara Yoshito
Saeki Makio
author_sort Kakihara Yoshito
title The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis
title_short The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis
title_full The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis
title_fullStr The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis
title_full_unstemmed The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis
title_sort r2tp chaperone complex: its involvement in snornp assembly and tumorigenesis
publisher De Gruyter
series Biomolecular Concepts
issn 1868-5021
1868-503X
publishDate 2014-12-01
description R2TP was originally identified in yeast Saccharomyces cerevisiae as Hsp90 interacting complex, and is composed of four different proteins: Rvb1, Rvb2, Tah1, and Pih1. This complex is well-conserved in eukaryotes, and is involved in many cellular processes such as snoRNP biogenesis, RNA polymerase assembly, PIKK signaling, and apoptosis. An increasing number of research related to R2TP suggests a linkage of its function with tumorigenesis. In this review, we provide an overview of several recent studies on R2TP that are related to cell proliferation and carcinogenesis, and propose a possible role of R2TP in tumorigenesis through regulating snoRNA/snoRNP biogenesis.
topic box c/d snornp
box h/aca snornp
r2tp
snornp biogenesis
tumorigenesis
url https://doi.org/10.1515/bmc-2014-0028
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