Heterogeneity and Remodeling of Ion Currents in Cultured Right Atrial Fibroblasts From Patients With Sinus Rhythm or Atrial Fibrillation

Heterogeneity and Remodeling of Ion Currents in Cultured Right Atrial Fibroblasts From Patients With Sinus Rhythm or Atrial Fibrillation

Cardiac fibroblasts express multiple voltage-dependent ion channels. Even though fibroblasts do not generate action potentials, they may influence cardiac electrophysiology by electrical coupling via gap junctions with cardiomyocytes, and through fibrosis. Here, we investigate the electrophysiologic...

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Bibliographic Details
Main Authors: Dorothee Jakob, Alexander Klesen, Elisa Darkow, Fabian A. Kari, Friedhelm Beyersdorf, Peter Kohl, Ursula Ravens, Rémi Peyronnet
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
voltage-gated channels
BKCa
heart
fibrosis
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.673891/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.673891/full

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