Optimized Synthesis of New N-Mustards Based on 2-Mercaptobenzoxazole Derivatives with Antitumor Activity

Optimized Synthesis of New N-Mustards Based on 2-Mercaptobenzoxazole Derivatives with Antitumor Activity

New di-(β-chloroethyl)-amides of some acids derived from 2-mercaptobenzoxazole were prepared by reaction of the corresponding pivalic mixed anhydrides with di-(β-chloroethyl)-amine. A study regarding the optimization of the chemical reactions was made for the case of di-(β-chloroethyl)-amines. The q...

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Bibliographic Details
Main Authors: Corina Cheptea, Valeriu Sunel, Ana Cezarina Morosanu, Dan Gheorghe Dimitriu, Mihaela Maria Dulcescu-Oprea, Mihai-Daniel Angheluta, Mihaela Miron, Cristina Delia Nechifor, Dana Ortansa Dorohoi, Razvan Nicolae Malancus
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomedicines
Subjects:
2-mercaptobenzoxazole
N-mustards
anti-inflammatory activity
Online Access:https://www.mdpi.com/2227-9059/9/5/476

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