Synthesis, ADMET Properties, and In Vitro Antimicrobial and Antibiofilm Activity of 5-Nitro-2-thiophenecarbaldehyde N-((E)-(5-Nitrothienyl)methylidene)hydrazone (KTU-286) against <i>Staphylococcus aureus</i> with Defined Resistance Mechanisms

Synthesis, ADMET Properties, and In Vitro Antimicrobial and Antibiofilm Activity of 5-Nitro-2-thiophenecarbaldehyde N-((E)-(5-Nitrothienyl)methylidene)hydrazone (KTU-286) against <i>Staphylococcus aureus</i> with Defined Resistance Mechanisms

The emergence of drug-resistant <i>Staphylococcus aureus</i> is responsible for high morbidity and mortality worldwide. New therapeutic options are needed to fight the increasing antimicrobial resistance among <i>S. aureus</i> in the clinical setting. We, therefore, character...

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Bibliographic Details
Main Authors: Povilas Kavaliauskas, Birute Grybaite, Vytautas Mickevicius, Ruta Petraitiene, Ramune Grigaleviciute, Rita Planciuniene, Philip Gialanella, Alius Pockevicius, Vidmantas Petraitis
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antibiotics
Subjects:
bisnitrothiophene
<i>Staphylococcus aureus</i>
MRSA
VRSA
antimicrobial
small molecules
Online Access:https://www.mdpi.com/2079-6382/9/9/612

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