PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment

PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment

Despite obesity reaching pandemic proportions, its impact on antigen-specific T cell responses is still unclear. We have recently demonstrated that obesity results in increased expression of PD-1 on T cells, and checkpoint blockade targeting PD-1/PD-L1 surprisingly resulted in greater clinical effic...

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Bibliographic Details
Main Authors: Catherine T. Le, Lam T. Khuat, Sofia E. Caryotakis, Marilyn Wang, Cordelia Dunai, Alan V. Nguyen, Logan V. Vick, Kevin M. Stoffel, Bruce R. Blazar, Arta M. Monjazeb, William J. Murphy, Athena M. Soulika
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
T cell
priming
programmed cell death protein 1
dendritic cells
experimental autoimmune encephalomyelitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.590568/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.590568/full

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