Diacylglycerol lipase a knockout mice demonstrate metabolic and behavioral phenotypes similar to those of cannabinoid receptor 1 knockout mice

Diacylglycerol lipase a knockout mice demonstrate metabolic and behavioral phenotypes similar to those of cannabinoid receptor 1 knockout mice

After creating >4650 knockouts (KOs) of independent mouse genes, we screened them by high-throughput phenotyping and found that cannabinoid receptor 1 (Cnr1) KO mice had the same lean phenotype published by others. We asked if our KOs of DAG lipase a or b (Dagla or Daglb), which catalyze biosynth...

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Bibliographic Details
Main Authors: David R Powell, Jason P Gay, Nathaniel eWilganowski, Deon eDoree, Katerina V Savelieva, Thomas H Lanthorn, Robert eRead, Peter eVogel, Gwenn M Hansen, Robert eBrommage, Zhi-Ming eDing, Urvi eDesai, Brian eZambrowicz
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Endocrinology
Subjects:
Anxiety
Depression
Endocannabinoids
Obesity
2-Arachidonoylglycerol
mouse knockout models
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00086/full

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