High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence

High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence

CD8 T-cell response efficiency critically depends on the TCR binding strength to peptide-MHC, i.e., the TCR binding avidity. A current challenge in onco-immunology lies in the evaluation of vaccine protocols selecting for tumor-specific T-cells of highest avidity, offering maximal immune protection...

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Bibliographic Details
Main Authors: Laura Carretero-Iglesia, Barbara Couturaud, Petra Baumgaertner, Julien Schmidt, Hélène Maby-El Hajjami, Daniel E. Speiser, Michael Hebeisen, Nathalie Rufer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
melanoma
vaccination
CD8 T-cells
peptide and CpG-B doses
NTAmers
TCR-pMHC binding avidity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03016/full

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