Halogen-Substituted Triazolethioacetamides as a Potent Skeleton for the Development of Metallo-β-Lactamase Inhibitors

Halogen-Substituted Triazolethioacetamides as a Potent Skeleton for the Development of Metallo-β-Lactamase Inhibitors

Metallo-β-lactamases (MβLs) are the target enzymes of β-lactam antibiotic resistance, and there are no effective inhibitors against MβLs available for clinic so far. In this study, thirteen halogen-substituted triazolethioacetamides were designed and synthesized a...

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Bibliographic Details
Main Authors: Yilin Zhang, Yong Yan, Lufan Liang, Jie Feng, Xuejun Wang, Li Li, Kewu Yang
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
halogen-substitutedtriazolethioacetamides
MβLs
inhibitor
Online Access:https://www.mdpi.com/1420-3049/24/6/1174

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