Tumor collagen framework from bright-field histology images predicts overall survival of breast carcinoma patients

Abstract Within the tumor microenvironment, specifically aligned collagen has been shown to stimulate tumor progression by directing the migration of metastatic cells along its structural framework. Tumor-associated collagen signatures (TACS) have been linked to breast cancer patient outcome. Robust...

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Bibliographic Details
Main Authors: Mindaugas Morkunas, Dovile Zilenaite, Aida Laurinaviciene, Povilas Treigys, Arvydas Laurinavicius
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94862-6