Age-dependent decrease and alternative splicing of methionine synthase mRNA in human cerebral cortex and an accelerated decrease in autism.

Age-dependent decrease and alternative splicing of methionine synthase mRNA in human cerebral cortex and an accelerated decrease in autism.

The folate and vitamin B12-dependent enzyme methionine synthase (MS) is highly sensitive to cellular oxidative status, and lower MS activity increases production of the antioxidant glutathione, while simultaneously decreasing more than 200 methylation reactions, broadly affecting metabolic activity....

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Bibliographic Details
Main Authors: Christina R Muratore, Nathaniel W Hodgson, Malav S Trivedi, Hamid M Abdolmaleky, Antonio M Persico, Carla Lintas, Suzanne De la Monte, Richard C Deth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3577685?pdf=render

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http://europepmc.org/articles/PMC3577685?pdf=render

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