Human-induced pluripotent stem cell-derived cardiomyocytes have limited I for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker

Human-induced pluripotent stem cell-derived cardiomyocytes have limited I for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker

Objective We investigated if there is I Ks , and if there is repolarization reserve by I Ks in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Design We used a specific KCNQ1/KCNE1 channel blocker, L-000768673, with an IC 50 of 9 nM, and four hERG-specific blockers, astemizol...

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Bibliographic Details
Main Authors:	Haoyu Zeng, Jixin Wang, Holly Clouse, Armando Lagrutta, Frederick Sannajust
Format:	Article
Language:	English
Published:	SAGE Publishing 2019-06-01
Series:	JRSM Cardiovascular Disease
Online Access:	https://doi.org/10.1177/2048004019854919

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