Human-induced pluripotent stem cell-derived cardiomyocytes have limited I for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker
Objective We investigated if there is I Ks , and if there is repolarization reserve by I Ks in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Design We used a specific KCNQ1/KCNE1 channel blocker, L-000768673, with an IC 50 of 9 nM, and four hERG-specific blockers, astemizol...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-06-01
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| Series: | JRSM Cardiovascular Disease |
| Online Access: | https://doi.org/10.1177/2048004019854919 |