Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
The genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network analysis, resulting in the prioritization of PPP1R3A a...
Main Authors: | Pablo Cordero, Victoria N. Parikh, Elizabeth T. Chin, Ayca Erbilgin, Michael J. Gloudemans, Ching Shang, Yong Huang, Alex C. Chang, Kevin S. Smith, Frederick Dewey, Kathia Zaleta, Michael Morley, Jeff Brandimarto, Nicole Glazer, Daryl Waggott, Aleksandra Pavlovic, Mingming Zhao, Christine S. Moravec, W. H. Wilson Tang, Jamie Skreen, Christine Malloy, Sridhar Hannenhalli, Hongzhe Li, Scott Ritter, Mingyao Li, Daniel Bernstein, Andrew Connolly, Hakon Hakonarson, Aldons J. Lusis, Kenneth B. Margulies, Anna A. Depaoli-Roach, Stephen B. Montgomery, Matthew T. Wheeler, Thomas Cappola, Euan A. Ashley |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-10591-5 |
Similar Items
-
Candida species Rewired Hyphae Developmental Programs for Chlamydospore Formation
by: Bettina Böttcher, et al.
Published: (2016-10-01) -
Rewiring, Forgetting and Learning
by: Alonso eMartinez-Canabal
Published: (2015-08-01) -
Rewiring for low power
by: 李廣為
Published: (2003) -
Identification of CAD candidate genes in GWAS loci and their expression in vascular cells[S]
by: Ayca Erbilgin, et al.
Published: (2013-07-01) -
Rewiring Meiosis for Crop Improvement
by: Pallas Kuo, et al.
Published: (2021-07-01)