Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
The genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network analysis, resulting in the prioritization of PPP1R3A a...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10591-5 |
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doaj-2ca5a8edf42d48a4acecfce1aa70adac2021-05-11T11:57:15ZengNature Publishing GroupNature Communications2041-17232019-06-0110111410.1038/s41467-019-10591-5Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failurePablo Cordero0Victoria N. Parikh1Elizabeth T. Chin2Ayca Erbilgin3Michael J. Gloudemans4Ching Shang5Yong Huang6Alex C. Chang7Kevin S. Smith8Frederick Dewey9Kathia Zaleta10Michael Morley11Jeff Brandimarto12Nicole Glazer13Daryl Waggott14Aleksandra Pavlovic15Mingming Zhao16Christine S. Moravec17W. H. Wilson Tang18Jamie Skreen19Christine Malloy20Sridhar Hannenhalli21Hongzhe Li22Scott Ritter23Mingyao Li24Daniel Bernstein25Andrew Connolly26Hakon Hakonarson27Aldons J. Lusis28Kenneth B. Margulies29Anna A. Depaoli-Roach30Stephen B. Montgomery31Matthew T. Wheeler32Thomas Cappola33Euan A. Ashley34Division of Cardiovascular Medicine, Stanford UniversityDivision of Cardiovascular Medicine, Stanford UniversityDivision of Cardiovascular Medicine, Stanford UniversityDivision of Cardiovascular Medicine, Stanford UniversityBiomedical Informatics Program, Stanford UniversityDivision of Cardiovascular Medicine, Stanford UniversityDivision of Cardiovascular Medicine, Stanford UniversityDivision of Cardiovascular Medicine, Stanford UniversityDepartment of Pathology, Stanford UniversityDivision of Cardiovascular Medicine, Stanford UniversityDivision of Cardiovascular Medicine, Stanford UniversityDivision of Cardiology, University of PennsylvaniaDepartment of Medicine, University of PennsylvaniaDepartment of Medicine, Boston University School of MedicineDivision of Cardiovascular Medicine, Stanford UniversityDivision of Cardiovascular Medicine, Stanford UniversityDepartment of Pediatrics, Stanford UniversityDepartment of Cardiovascular and Metabolic Sciences, Lerner Research InstituteDepartment of Cardiovascular and Metabolic Sciences, Lerner Research InstituteProvidence Medical Group—MilwaukieCenter for Bioinformatics and Computational Biology, University of MarylandCenter for Bioinformatics and Computational Biology, University of MarylandBiostatistics and Epidemiology, University of PennsylvaniaDivision of Cardiology, University of PennsylvaniaBiostatistics and Epidemiology, University of PennsylvaniaDepartment of Pediatrics, Stanford UniversityDepartment of Pathology, University of California San FranciscoDepartment of Pediatrics, The Children’s Hospital of PhiladelphiaDepartments of Medicine, University of California Los AngelesDivision of Cardiology, University of PennsylvaniaSchool of Medicine, Indiana UniversityDepartment of Pathology, Stanford UniversityDivision of Cardiovascular Medicine, Stanford UniversityDivision of Cardiology, University of PennsylvaniaDivision of Cardiovascular Medicine, Stanford UniversityThe genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network analysis, resulting in the prioritization of PPP1R3A as a heart failure gene.https://doi.org/10.1038/s41467-019-10591-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Pablo Cordero Victoria N. Parikh Elizabeth T. Chin Ayca Erbilgin Michael J. Gloudemans Ching Shang Yong Huang Alex C. Chang Kevin S. Smith Frederick Dewey Kathia Zaleta Michael Morley Jeff Brandimarto Nicole Glazer Daryl Waggott Aleksandra Pavlovic Mingming Zhao Christine S. Moravec W. H. Wilson Tang Jamie Skreen Christine Malloy Sridhar Hannenhalli Hongzhe Li Scott Ritter Mingyao Li Daniel Bernstein Andrew Connolly Hakon Hakonarson Aldons J. Lusis Kenneth B. Margulies Anna A. Depaoli-Roach Stephen B. Montgomery Matthew T. Wheeler Thomas Cappola Euan A. Ashley |
| spellingShingle |
Pablo Cordero Victoria N. Parikh Elizabeth T. Chin Ayca Erbilgin Michael J. Gloudemans Ching Shang Yong Huang Alex C. Chang Kevin S. Smith Frederick Dewey Kathia Zaleta Michael Morley Jeff Brandimarto Nicole Glazer Daryl Waggott Aleksandra Pavlovic Mingming Zhao Christine S. Moravec W. H. Wilson Tang Jamie Skreen Christine Malloy Sridhar Hannenhalli Hongzhe Li Scott Ritter Mingyao Li Daniel Bernstein Andrew Connolly Hakon Hakonarson Aldons J. Lusis Kenneth B. Margulies Anna A. Depaoli-Roach Stephen B. Montgomery Matthew T. Wheeler Thomas Cappola Euan A. Ashley Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure Nature Communications |
| author_facet |
Pablo Cordero Victoria N. Parikh Elizabeth T. Chin Ayca Erbilgin Michael J. Gloudemans Ching Shang Yong Huang Alex C. Chang Kevin S. Smith Frederick Dewey Kathia Zaleta Michael Morley Jeff Brandimarto Nicole Glazer Daryl Waggott Aleksandra Pavlovic Mingming Zhao Christine S. Moravec W. H. Wilson Tang Jamie Skreen Christine Malloy Sridhar Hannenhalli Hongzhe Li Scott Ritter Mingyao Li Daniel Bernstein Andrew Connolly Hakon Hakonarson Aldons J. Lusis Kenneth B. Margulies Anna A. Depaoli-Roach Stephen B. Montgomery Matthew T. Wheeler Thomas Cappola Euan A. Ashley |
| author_sort |
Pablo Cordero |
| title |
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure |
| title_short |
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure |
| title_full |
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure |
| title_fullStr |
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure |
| title_full_unstemmed |
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure |
| title_sort |
pathologic gene network rewiring implicates ppp1r3a as a central regulator in pressure overload heart failure |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-06-01 |
| description |
The genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network analysis, resulting in the prioritization of PPP1R3A as a heart failure gene. |
| url |
https://doi.org/10.1038/s41467-019-10591-5 |
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