Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy

Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy

Abstract Background Out of the myriad of complications associated with septic shock, septic-associated encephalopathy (SAE) carries a significant risk of morbidity and mortality. Blood-brain-barrier (BBB) impairment, which subsequently leads to increased vascular permeability, has been associated wi...

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Bibliographic Details
Main Authors: Bereketeab Haileselassie, Amit U. Joshi, Paras S. Minhas, Riddhita Mukherjee, Katrin I. Andreasson, Daria Mochly-Rosen
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
Drp1
Neuroinflammation
Blood brain barrier
P110
Sepsis
Online Access:https://doi.org/10.1186/s12974-019-1689-8

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