Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease

Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease

Autophagy has been implicated in the pathogenesis of chronic kidney disease (CKD). Transcription factor EB (TFEB) is a master controller of autophagy. However, the pathophysiological roles of TFEB in modulating autophagy and tubulointerstitial injury in CKD are unknown. This study aimed to determine...

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Bibliographic Details
Main Authors: Huiqi Yuan, Chaoyang Zheng, Li Zhu, Ziqing Song, Linfeng Dai, Qingzong Hu, Lei Wang, Yang Chen, Jing Xiong
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chronic kidney disease
Inflammation
Fibrosis
TFEB
Autophagy
Adenine diet
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220311410

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