Downregulation of Tim-1 inhibits the proliferation, migration and invasion of glioblastoma cells via the miR-133a/TGFBR1 axis and the restriction of Wnt/β-catenin pathway

Downregulation of Tim-1 inhibits the proliferation, migration and invasion of glioblastoma cells via the miR-133a/TGFBR1 axis and the restriction of Wnt/β-catenin pathway

Abstract Background Glioblastoma remains one of the most lethal brain cancers. T-cell immunoglobulin and mucin domain 1 (Tim-1) is associated with various immune diseases. The molecular mechanism of Tim-1 in regulating glioblastoma cell proliferation, invasion, and migration is still unknown. Moreov...

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Bibliographic Details
Main Authors: Li Wei, Ya Peng, Naiyuan Shao, Peng Zhou
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Cancer Cell International
Subjects:
Glioblastoma
T-cell immunoglobulin and mucin domain 1
MicroRNA-133a/TGFBR1 axis
Proliferation
Invasion
Migration
Online Access:https://doi.org/10.1186/s12935-021-02036-1

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