Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing <i>Klebsiella pneumoniae</i> infection in Nigeria
We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led...
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2012-06-01
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| Series: | African Journal of Laboratory Medicine |
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| Online Access: | https://ajlmonline.org/index.php/ajlm/article/view/16 |
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doaj-2c8b9265c9f74923b72f0d3683ef9d6f2020-11-25T00:16:16ZengAOSISAfrican Journal of Laboratory Medicine2225-20022225-20102012-06-0111e1e410.4102/ajlm.v1i1.1614Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing <i>Klebsiella pneumoniae</i> infection in NigeriaOladipo A. Aboderin0Olufemi Adefehinti1Babatunde W. Odetoyin2Amadin A. Olotu3Iruka N. Okeke4Olugbenga Adeodu5Department of Medical Microbiology and Parasitology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, NigeriaDepartment of Paediatrics, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, NigeriaDepartment of Medical Microbiology and Parasitology, Obafemi Awolowo University, Ile-Ife, Osun StateDepartment of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-IfeDepartment of Biology, Haverford College, Haverford, PADepartment of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-IfeWe report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led to sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because of diagnostic limitations and consequent treatment failure involving prolonged supportive therapy.https://ajlmonline.org/index.php/ajlm/article/view/16septicaemiaCTX-M-15Klebsiella pneumoniaeNigeria |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Oladipo A. Aboderin Olufemi Adefehinti Babatunde W. Odetoyin Amadin A. Olotu Iruka N. Okeke Olugbenga Adeodu |
| spellingShingle |
Oladipo A. Aboderin Olufemi Adefehinti Babatunde W. Odetoyin Amadin A. Olotu Iruka N. Okeke Olugbenga Adeodu Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing <i>Klebsiella pneumoniae</i> infection in Nigeria African Journal of Laboratory Medicine septicaemia CTX-M-15 Klebsiella pneumoniae Nigeria |
| author_facet |
Oladipo A. Aboderin Olufemi Adefehinti Babatunde W. Odetoyin Amadin A. Olotu Iruka N. Okeke Olugbenga Adeodu |
| author_sort |
Oladipo A. Aboderin |
| title |
Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing <i>Klebsiella pneumoniae</i> infection in Nigeria |
| title_short |
Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing <i>Klebsiella pneumoniae</i> infection in Nigeria |
| title_full |
Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing <i>Klebsiella pneumoniae</i> infection in Nigeria |
| title_fullStr |
Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing <i>Klebsiella pneumoniae</i> infection in Nigeria |
| title_full_unstemmed |
Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing <i>Klebsiella pneumoniae</i> infection in Nigeria |
| title_sort |
prolonged febrile illness due to ctx-m-15 extendedspectrum β-lactamase-producing <i>klebsiella pneumoniae</i> infection in nigeria |
| publisher |
AOSIS |
| series |
African Journal of Laboratory Medicine |
| issn |
2225-2002 2225-2010 |
| publishDate |
2012-06-01 |
| description |
We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led to sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because of diagnostic limitations and consequent treatment failure involving prolonged supportive therapy. |
| topic |
septicaemia CTX-M-15 Klebsiella pneumoniae Nigeria |
| url |
https://ajlmonline.org/index.php/ajlm/article/view/16 |
| work_keys_str_mv |
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1725383599711059968 |