Alzheimer disease in post-menopausal women: Intervene in the critical window period

Alzheimer disease (AD) is a crippling neurodegenerative disorder. It is more common in females after menopause. Estrogen probably has a protective role in cognitive decline. Large amount of research has been carried out to see the benefits of hormone replacement therapy with regards to Alzheimer sti...

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Bibliographic Details
Main Authors: Nayer Jamshed, Fouzia Firdaus Ozair, Praveen Aggarwal, Meera Ekka
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Journal of Mid-Life Health
Subjects:
Online Access:http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2014;volume=5;issue=1;spage=38;epage=40;aulast=Jamshed
Description
Summary:Alzheimer disease (AD) is a crippling neurodegenerative disorder. It is more common in females after menopause. Estrogen probably has a protective role in cognitive decline. Large amount of research has been carried out to see the benefits of hormone replacement therapy with regards to Alzheimer still its neuroprotective effect is not established. Recent studies suggest a reduced risk of AD and improved cognitive functioning of post-menopausal women who used 17 β-estradiol in the critical period. Use of 17 β-estradiol in young and healthy post-menopausal women yields the maximum benefit when the neurons are intact or neuronal stress has just started. Hence intervention in the critical period is key in the prevention or delay of AD in post-menopausal women.
ISSN:0976-7800
0976-7819