Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin/Islr in Cancer Fibrosis

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin/Islr in Cancer Fibrosis

Fibroblasts synthesise the extracellular matrix (ECM) such as collagen and elastin, the excessive accumulation of which can lead to fibrosis and organ dysfunction under pathological conditions. Cancer-associated fibroblasts (CAFs) are major constituents of the tumour microenvironment (TME) that acco...

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Bibliographic Details
Main Authors: Masahide Takahashi, Hiroki Kobayashi, Yasuyuki Mizutani, Akitoshi Hara, Tadashi Iida, Yuki Miyai, Naoya Asai, Atsushi Enomoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Meflin
Islr
cancer-associated fibroblast
mesenchymal stromal/stem cell
tumour microenvironment
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.749924/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.749924/full

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