Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
Ewing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22)(q24;q12). This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessa...
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2011-01-01
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Online Access: | http://dx.doi.org/10.1155/2011/598704 |
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doaj-2c73052565854f298d6a7b5cb0f3412e2020-11-25T00:18:26ZengHindawi LimitedSarcoma1357-714X1369-16432011-01-01201110.1155/2011/598704598704Cell Cycle Deregulation in Ewing's Sarcoma PathogenesisAshley A. Kowalewski0R. Lor Randall1Stephen L. Lessnick2Department of Oncological Sciences, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USACenter for Children's Cancer Research, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USADepartment of Oncological Sciences, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USAEwing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22)(q24;q12). This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessary for oncogenesis. One key feature of oncogenic transformation is dysregulation of cell cycle control. It is therefore likely that EWS/FLI and other cooperating mutations in Ewing's sarcoma modulate the cell cycle to facilitate tumorigenesis. This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered.http://dx.doi.org/10.1155/2011/598704 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ashley A. Kowalewski R. Lor Randall Stephen L. Lessnick |
spellingShingle |
Ashley A. Kowalewski R. Lor Randall Stephen L. Lessnick Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis Sarcoma |
author_facet |
Ashley A. Kowalewski R. Lor Randall Stephen L. Lessnick |
author_sort |
Ashley A. Kowalewski |
title |
Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis |
title_short |
Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis |
title_full |
Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis |
title_fullStr |
Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis |
title_full_unstemmed |
Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis |
title_sort |
cell cycle deregulation in ewing's sarcoma pathogenesis |
publisher |
Hindawi Limited |
series |
Sarcoma |
issn |
1357-714X 1369-1643 |
publishDate |
2011-01-01 |
description |
Ewing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22)(q24;q12). This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessary for oncogenesis. One key feature of oncogenic transformation is dysregulation of cell cycle control. It is therefore likely that EWS/FLI and other cooperating mutations in Ewing's sarcoma modulate the cell cycle to facilitate tumorigenesis. This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered. |
url |
http://dx.doi.org/10.1155/2011/598704 |
work_keys_str_mv |
AT ashleyakowalewski cellcyclederegulationinewingssarcomapathogenesis AT rlorrandall cellcyclederegulationinewingssarcomapathogenesis AT stephenllessnick cellcyclederegulationinewingssarcomapathogenesis |
_version_ |
1725376586033659904 |