Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis

Ewing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22)(q24;q12). This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessa...

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Main Authors: Ashley A. Kowalewski, R. Lor Randall, Stephen L. Lessnick
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Sarcoma
Online Access:http://dx.doi.org/10.1155/2011/598704
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spelling doaj-2c73052565854f298d6a7b5cb0f3412e2020-11-25T00:18:26ZengHindawi LimitedSarcoma1357-714X1369-16432011-01-01201110.1155/2011/598704598704Cell Cycle Deregulation in Ewing's Sarcoma PathogenesisAshley A. Kowalewski0R. Lor Randall1Stephen L. Lessnick2Department of Oncological Sciences, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USACenter for Children's Cancer Research, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USADepartment of Oncological Sciences, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USAEwing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22)(q24;q12). This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessary for oncogenesis. One key feature of oncogenic transformation is dysregulation of cell cycle control. It is therefore likely that EWS/FLI and other cooperating mutations in Ewing's sarcoma modulate the cell cycle to facilitate tumorigenesis. This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered.http://dx.doi.org/10.1155/2011/598704
collection DOAJ
language English
format Article
sources DOAJ
author Ashley A. Kowalewski
R. Lor Randall
Stephen L. Lessnick
spellingShingle Ashley A. Kowalewski
R. Lor Randall
Stephen L. Lessnick
Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
Sarcoma
author_facet Ashley A. Kowalewski
R. Lor Randall
Stephen L. Lessnick
author_sort Ashley A. Kowalewski
title Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
title_short Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
title_full Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
title_fullStr Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
title_full_unstemmed Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
title_sort cell cycle deregulation in ewing's sarcoma pathogenesis
publisher Hindawi Limited
series Sarcoma
issn 1357-714X
1369-1643
publishDate 2011-01-01
description Ewing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22)(q24;q12). This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessary for oncogenesis. One key feature of oncogenic transformation is dysregulation of cell cycle control. It is therefore likely that EWS/FLI and other cooperating mutations in Ewing's sarcoma modulate the cell cycle to facilitate tumorigenesis. This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered.
url http://dx.doi.org/10.1155/2011/598704
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AT rlorrandall cellcyclederegulationinewingssarcomapathogenesis
AT stephenllessnick cellcyclederegulationinewingssarcomapathogenesis
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