A Study of Progesterone Receptor (PR) Expression in Meningiomas, and its Correlation with Clinicopathological Parameters

• Main Author: Shenbagam Jeevakarunyam Muthukanagarajan
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2018-09-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: brain tumour; grading of meningiomas; hormonal receptor evaluation of meningiomas
• Online Access: https://jcdr.net/articles/PDF/11972/34338_CE(RA1)_F(T)_PF1(AGAK)_PFA(AK)_PB(AG_OM)_PN(SS).pdf
• ISSN: 2249-782X; 0973-709X

Introduction: Meningiomas are the most common benign Central nervous system neoplasms with higher prevalence in women. Clinical and epidemiological data reveal that meningiomas are hormone sensitive tumours and they have been found to express hormonal receptors. Though majority of meningiomas are benign, they lead to significant morbidity and mortality. Aim: This study deals with the immunohistochemical expression of Progesterone Receptor (PR) in meningiomas in correlation with various clinicopathological parameters and behaviour of the tumour. Materials and Methods: This was a retrospective and prospective study carried out at neuropathology department in a tertiary care hospital during a consecutive period of three years from 2013 to 2016. The antibodies to PR were used for 60 randomly selected cases of meningioma operated during a consecutive period of three years. The PR expression in relation to age and sex of patient, site and various histopathological grades of the tumour and their rates of recurrence were studied. Statistical analysis was carried out using SPSS software version 17. Various tests used in the study were the chi-square test for discrete variables and the t-test for continuous variables. Results: Immunohistochemical analysis revealed PR expression in 66.7% of cases. In comparison with grade I meningiomas the PR expression in high grade (grade II and III) meningiomas were found to be from weak to absent. This shows a positive association between low rates of expression of PR and increased tumour aggressiveness. Conclusion: It is concluded that expression of PR by the tumour in correlation with other histopathological features especially histological grade of the tumour has been considered as a useful prognostic tool in assessing the behaviour of meningiomas.