sCD4-17b bifunctional protein: Extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates

sCD4-17b bifunctional protein: Extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates

<p>Abstract</p> <p>Background</p> <p>We previously described a potent recombinant HIV-1 neutralizing protein, sCD4-17b, composed of soluble CD4 attached via a flexible polypeptide linker to an SCFv of the 17b human monoclonal antibody directed against the highly conserv...

Full description

Bibliographic Details
Main Authors:	Dey Barna, Bundoc Virgilio, Villarroel Vadim A, Lagenaur Laurel A, Berger Edward A
Format:	Article
Language:	English
Published:	BMC 2010-02-01
Series:	Retrovirology
Online Access:	http://www.retrovirology.com/content/7/1/11

Similar Items

Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies
by: Julien J, et al.
Published: (2012-09-01)

Validation of an automated system for aliquoting of HIV-1 Env-pseudotyped virus stocks.
by: Anke Schultz, et al.
Published: (2018-01-01)

An automated HIV-1 Env-pseudotyped virus production for global HIV vaccine trials.
by: Anke Schultz, et al.
Published: (2012-01-01)

Targeting HIV reservoir by DART molecules that recruit T cells to HIV Env expressing cells: comparison of HIV arms derived from broadly reactive neutralizing or non-neutralizing anti-Env antibodies
by: J.L. Nordstrom, et al.
Published: (2015-12-01)

Longitudinally Profiling Neutralizing Antibody Response to SARS Coronavirus with Pseudotypes
by: Nigel J. Temperton, et al.
Published: (2005-03-01)

Chimeric influenza haemagglutinins: Generation and use in pseudotype neutralization assays
by: Francesca Ferrara, et al.
Published: (2017-01-01)

Reliability of pseudotyped influenza viral particles in neutralizing antibody detection.
by: Jinghui Yang, et al.
Published: (2014-01-01)

Pseudotype-based neutralization assays for influenza: a systematic analysis
by: George William Carnell, et al.
Published: (2015-04-01)

Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FIT45
by: Alexander Falkenhagen, et al.
Published: (2017-06-01)

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer.
by: Rajesh Kumar, et al.
Published: (2021-04-01)

Novel vomputational methods for predicting epitopes of potent and broadly neutralizing HIV-1 antibodies
by: Evans MC, et al.
Published: (2012-09-01)

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice
by: Andrew T. McGuire, et al.
Published: (2016-02-01)

Quantification of Lyssavirus-Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudotype Particles
by: Sarah Moeschler, et al.
Published: (2016-09-01)

Chikungunya virus glycoproteins pseudotype with lentiviral vectors and reveal a broad spectrum of cellular tropism.
by: Dakang Hu, et al.
Published: (2014-01-01)

Sequential immunizations with a panel of HIV-1 Env virus-like particles coach immune system to make broadly neutralizing antibodies
by: Teena Mohan, et al.
Published: (2018-05-01)

Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge.
by: Marie Borggren, et al.
Published: (2011-01-01)

The Use of Hyperimmune Chicken Reference Sera Is Not Appropriate for the Validation of Influenza Pseudotype Neutralization Assays
by: Francesca Ferrara, et al.
Published: (2017-09-01)

Coronavirus Pseudotypes for All Circulating Human Coronaviruses for Quantification of Cross-Neutralizing Antibody Responses
by: Alexander Thomas Sampson, et al.
Published: (2021-08-01)

Induction of broadly neutralising HCV antibodies in mice by integration-deficient lentiviral vector-based pseudotyped particles.
by: Yao Deng, et al.
Published: (2013-01-01)

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies.
by: Rogier W Sanders, et al.
Published: (2013-09-01)

Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection
by: Taylor B. Engdahl, et al.
Published: (2021-05-01)

Broad and potent neutralization of HIV-1 by human-llama fusion antibodies derived from immunized llamas
by: McCoy LE, et al.
Published: (2012-09-01)

Neutralizing antibodies elicited in rabbits by patient-derived Env trimer immunization
by: Heyndrickx L, et al.
Published: (2012-09-01)

Design of an HIV Env antigen that binds with high affinity to antibodies against linear, conformational and broadly neutralizing epitopes within V1/V2
by: Liao L, et al.
Published: (2012-09-01)

Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
by: Changhai Lei, et al.
Published: (2020-04-01)

Package of NDV-pseudotyped HIV-Luc virus and its application in the neutralization assay for NDV infection.
by: Bin Wang, et al.
Published: (2014-01-01)

Screening test for neutralizing antibodies against yellow fever virus, based on a flavivirus pseudotype.
by: Séverine Mercier-Delarue, et al.
Published: (2017-01-01)

Construction of SHIVs expressing quaternary neutralization epitopes in Env and mimicking the neutralization phenotype of typical HIV-1 isolates
by: Theis JF, et al.
Published: (2012-09-01)

A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein
by: Aimin Tang, et al.
Published: (2019-09-01)

Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1
by: George K. Lewis, et al.
Published: (2015-09-01)

Development and application of a new class of potent bifunctional organocatalysts
by: Farley, Alistair J. M.
Published: (2015)

Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes
by: Hélio A. Tomás, et al.
Published: (2019-12-01)

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays
by: Katharine H.D. Crawford, et al.
Published: (2020-05-01)

Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity
by: Seth H. Pincus, et al.
Published: (2021-07-01)

Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner
by: Caitlin E. Mullarkey, et al.
Published: (2016-10-01)

Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol
by: Jose Manuel Condor Capcha, et al.
Published: (2021-01-01)

Development and characterisation of pseudotype HIV vectors
by: Strang, Blair Lewis
Published: (2003)

Neutralization assay with SARS-CoV-1 and SARS-CoV-2 spike pseudotyped murine leukemia virions
by: Yue Zheng, et al.
Published: (2021-01-01)

Development and effectiveness of pseudotyped SARS-CoV-2 system as determined by neutralizing efficiency and entry inhibition test in vitroHighlights
by: Ren Yang, et al.
Published: (2020-12-01)

Sums of SCD sets and their applications to SCD operators and narrow operators
by: Kadets Vladimir, et al.
Published: (2010-02-01)