Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins
Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05092-w |
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doaj-2c460a63a313487ab66f065d9084faaf2021-05-11T09:40:43ZengNature Publishing GroupNature Communications2041-17232018-07-019111010.1038/s41467-018-05092-wWidespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteinsAlexander P. Hynes0Geneviève M. Rousseau1Daniel Agudelo2Adeline Goulet3Beatrice Amigues4Jeremy Loehr5Dennis A. Romero6Christophe Fremaux7Philippe Horvath8Yannick Doyon9Christian Cambillau10Sylvain Moineau11Département de biochimie, de microbiologie, et de bioinformatique, Faculté des sciences et de génie, Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Université LavalDépartement de biochimie, de microbiologie, et de bioinformatique, Faculté des sciences et de génie, Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Université LavalCentre Hospitalier Universitaire de Québec Research Center, Université LavalArchitecture et Fonction des Macromolécules Biologiques, Aix-Marseille Université, Campus de LuminyArchitecture et Fonction des Macromolécules Biologiques, Aix-Marseille Université, Campus de LuminyCentre Hospitalier Universitaire de Québec Research Center, Université LavalDuPont Nutrition and HealthDuPont Nutrition and HealthDuPont Nutrition and HealthCentre Hospitalier Universitaire de Québec Research Center, Université LavalArchitecture et Fonction des Macromolécules Biologiques, Aix-Marseille Université, Campus de LuminyDépartement de biochimie, de microbiologie, et de bioinformatique, Faculté des sciences et de génie, Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Université LavalSome phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications.https://doi.org/10.1038/s41467-018-05092-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alexander P. Hynes Geneviève M. Rousseau Daniel Agudelo Adeline Goulet Beatrice Amigues Jeremy Loehr Dennis A. Romero Christophe Fremaux Philippe Horvath Yannick Doyon Christian Cambillau Sylvain Moineau |
| spellingShingle |
Alexander P. Hynes Geneviève M. Rousseau Daniel Agudelo Adeline Goulet Beatrice Amigues Jeremy Loehr Dennis A. Romero Christophe Fremaux Philippe Horvath Yannick Doyon Christian Cambillau Sylvain Moineau Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins Nature Communications |
| author_facet |
Alexander P. Hynes Geneviève M. Rousseau Daniel Agudelo Adeline Goulet Beatrice Amigues Jeremy Loehr Dennis A. Romero Christophe Fremaux Philippe Horvath Yannick Doyon Christian Cambillau Sylvain Moineau |
| author_sort |
Alexander P. Hynes |
| title |
Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins |
| title_short |
Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins |
| title_full |
Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins |
| title_fullStr |
Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins |
| title_full_unstemmed |
Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins |
| title_sort |
widespread anti-crispr proteins in virulent bacteriophages inhibit a range of cas9 proteins |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-07-01 |
| description |
Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications. |
| url |
https://doi.org/10.1038/s41467-018-05092-w |
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