A Perspective on Reagent Diversity and Non-covalent Binding of Reactive Carbonyl Species (RCS) and Effector Reagents in Non-enzymatic Glycation (NEG): Mechanistic Considerations and Implications for Future Research

A Perspective on Reagent Diversity and Non-covalent Binding of Reactive Carbonyl Species (RCS) and Effector Reagents in Non-enzymatic Glycation (NEG): Mechanistic Considerations and Implications for Future Research

This perspective focuses on illustrating the underappreciated connections between reactive carbonyl species (RCS), initial binding in the nonenzymatic glycation (NEG) process, and nonenzymatic covalent protein modification (here termed NECPM). While glucose is the central species involved in NEG, re...

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Bibliographic Details
Main Authors: Kenneth J. Rodnick, R. W. Holman, Pamela S. Ropski, Mingdong Huang, Arthur L. M. Swislocki
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Chemistry
Subjects:
reactive carbonyl species
glycation
diabetes
glucose
phosphate
mechanism
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2017.00039/full

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