Investigation of a MMP-2 activity-dependent anchoring probe for nuclear imaging of cancer.

Investigation of a MMP-2 activity-dependent anchoring probe for nuclear imaging of cancer.

Since matrix metalloproteinase-2 (MMP-2) is an important marker of tumor malignancy, we developed an original drug design strategy, MMP-2 activity dependent anchoring probes (MDAP), for use in MMP-2 activity imaging, and evaluated the usefulness of this probe in in vitro and in vivo experiments.We d...

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Bibliographic Details
Main Authors: Takashi Temma, Hirofumi Hanaoka, Aki Yonezawa, Naoya Kondo, Kohei Sano, Takeharu Sakamoto, Motoharu Seiki, Masahiro Ono, Hideo Saji
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4092090?pdf=render

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