Depot medroxyprogesterone acetate (DMPA) enhances susceptibility and increases the window of vulnerability to HIV-1 in humanized mice

Depot medroxyprogesterone acetate (DMPA) enhances susceptibility and increases the window of vulnerability to HIV-1 in humanized mice

Abstract The progestin-based hormonal contraceptive Depot Medroxyprogesterone Acetate (DMPA) is widely used in sub-Saharan Africa, where HIV-1 is endemic. Meta-analyses have shown that women using DMPA are 40% more likely than women not using hormonal contraceptives to acquire Human Immunodeficiency...

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Bibliographic Details
Main Authors: Jocelyn M. Wessels, Philip V. Nguyen, Danielle Vitali, Kristen Mueller, Fatemeh Vahedi, Allison M. Felker, Haley A. Dupont, Puja Bagri, Chris P. Verschoor, Alexandre Deshiere, Tony Mazzulli, Michel J. Tremblay, Ali A. Ashkar, Charu Kaushic
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83242-9

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